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From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome

Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent aneuploidy observed in the human population and represents the most common genetic form of intellectual disability and early-onset Alzheimer’s disease (AD). Individuals with DS exhibit a wide spectrum of clinical prese...

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Principais autores: L. Ashley Watson, Hiruy S. Meharena
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-05-01
Serier:Frontiers in Genetics
Fag:
down syndrome
neurodevelomental disorders
neurodegenenerative diseases
human tissue
cell culture models
human stem cells
Online adgang:https://www.frontiersin.org/articles/10.3389/fgene.2023.1198129/full
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