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The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

ABSTRACT Lysyl-diacylglycerol (Lys-DAG) was identified three decades ago in Mycobacterium phlei, but the biosynthetic pathway and function of this aminoacylated lipid have since remained uncharacterized. Combining genetic methods, mass spectrometry, and biochemical approaches, we show that the multi...

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Principais autores: Cameron P. Gill, Christopher Phan, Vivien Platt, Danielle Worrell, Thomas Andl, Hervé Roy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2023-10-01
coleção:Microbiology Spectrum
Assuntos:
tRNA
diacylglycerol
Corynebacterium
Mycobacterium
antibiotic resistance
Acesso em linha:https://journals.asm.org/doi/10.1128/spectrum.01429-23
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