The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

ABSTRACT Lysyl-diacylglycerol (Lys-DAG) was identified three decades ago in Mycobacterium phlei, but the biosynthetic pathway and function of this aminoacylated lipid have since remained uncharacterized. Combining genetic methods, mass spectrometry, and biochemical approaches, we show that the multi...

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Hlavní autoři:	Cameron P. Gill, Christopher Phan, Vivien Platt, Danielle Worrell, Thomas Andl, Hervé Roy
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2023-10-01
Edice:	Microbiology Spectrum
Témata:	tRNA diacylglycerol Corynebacterium Mycobacterium antibiotic resistance
On-line přístup:	https://journals.asm.org/doi/10.1128/spectrum.01429-23
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