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The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

ABSTRACT Lysyl-diacylglycerol (Lys-DAG) was identified three decades ago in Mycobacterium phlei, but the biosynthetic pathway and function of this aminoacylated lipid have since remained uncharacterized. Combining genetic methods, mass spectrometry, and biochemical approaches, we show that the multi...

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Principais autores: Cameron P. Gill, Christopher Phan, Vivien Platt, Danielle Worrell, Thomas Andl, Hervé Roy
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2023-10-01
סדרה:Microbiology Spectrum
נושאים:
tRNA
diacylglycerol
Corynebacterium
Mycobacterium
antibiotic resistance
גישה מקוונת:https://journals.asm.org/doi/10.1128/spectrum.01429-23
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