Potential therapeutic interventions for fragile X syndrome

por Levenga, Josien, de Vrij, Femke M.S., Oostra, Ben A., Willemsen, Rob
Publicado 2010

Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons

por Levenga, Josien, Buijsen, Ronald A.M., Rifé, Maria, Moine, Herve, Nelson, David L., Oostra, Ben A., Willemsen, Rob, de Vrij, Femke M.S.
Publicado 2009

Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms

por Zampeta, F Isabella, Sonzogni, Monica, Niggl, Eva, Lendemeijer, Bas, Smeenk, Hilde, de Vrij, Femke M S, Kushner, Steven A, Distel, Ben, Elgersma, Ype
Publicado en Hum Mol Genet (2020)

Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models

por Bauer, Lisa, Lendemeijer, Bas, Leijten, Lonneke, Embregts, Carmen W. E., Rockx, Barry, Kushner, Steven A., de Vrij, Femke M. S., van Riel, Debby
Publicado en mSphere (2021)

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

por de Vrij, Femke M.S., Levenga, Josien, van der Linde, Herma C., Koekkoek, Sebastiaan K., De Zeeuw, Chris I., Nelson, David L., Oostra, Ben A., Willemsen, Rob
Publicado 2008

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

por Lindsten, Kristina, de Vrij, Femke M.S., Verhoef, Lisette G.G.C., Fischer, David F., van Leeuwen, Fred W., Hol, Elly M., Masucci, Maria G., Dantuma, Nico P.
Publicado 2002

A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function

por Okray, Zeynep, de Esch, Celine EF, Van Esch, Hilde, Devriendt, Koen, Claeys, Annelies, Yan, Jiekun, Verbeeck, Jelle, Froyen, Guy, Willemsen, Rob, de Vrij, Femke MS, Hassan, Bassem A
Publicado en EMBO Mol Med (2015)

An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum

por Higuera, Gustavo A., Iaffaldano, Grazia, Bedar, Meiwand, Shpak, Guy, Broersen, Robin, Munshi, Shashini T., Dupont, Catherine, Gribnau, Joost, de Vrij, Femke M. S., Kushner, Steven A., De Zeeuw, Chris I.
Publicado en Sci Rep (2017)

Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation

por de Esch, Celine E.F., Ghazvini, Mehrnaz, Loos, Friedemann, Schelling-Kazaryan, Nune, Widagdo, W., Munshi, Shashini T., van der Wal, Erik, Douben, Hannie, Gunhanlar, Nilhan, Kushner, Steven A., Pijnappel, W.W.M. Pim, de Vrij, Femke M.S., Geijsen, Niels, Gribnau, Joost, Willemsen, Rob
Publicado en Stem Cell Reports (2014)

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

por García-León, Juan Antonio, Kumar, Manoj, Boon, Ruben, Chau, David, One, Jennifer, Wolfs, Esther, Eggermont, Kristel, Berckmans, Pieter, Gunhanlar, Nilhan, de Vrij, Femke, Lendemeijer, Bas, Pavie, Benjamin, Corthout, Nikky, Kushner, Steven A., Dávila, José Carlos, Lambrichts, Ivo, Hu, Wei-Shou, Verfaillie, Catherine M.
Publicado en Stem Cell Reports (2018)

Phenotypic Differences between Asian and African Lineage Zika Viruses in Human Neural Progenitor Cells

por Anfasa, Fatih, Siegers, Jurre Y., van der Kroeg, Mark, Mumtaz, Noreen, Stalin Raj, V., de Vrij, Femke M. S., Widagdo, W., Gabriel, Gülsah, Salinas, Sara, Simonin, Yannick, Reusken, Chantal, Kushner, Steven A., Koopmans, Marion P. G., Haagmans, Bart, Martina, Byron E. E., van Riel, Debby
Publicado en mSphere (2017)

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

por Vanhauwaert, Roeland, Kuenen, Sabine, Masius, Roy, Bademosi, Adekunle, Manetsberger, Julia, Schoovaerts, Nils, Bounti, Laura, Gontcharenko, Serguei, Swerts, Jef, Vilain, Sven, Picillo, Marina, Barone, Paolo, Munshi, Shashini T, de Vrij, Femke MS, Kushner, Steven A, Gounko, Natalia V, Mandemakers, Wim, Bonifati, Vincenzo, Meunier, Frederic A, Soukup, Sandra‐Fausia, Verstreken, Patrik
Publicado en EMBO J (2017)

ACO2 homozygous missense mutation associated with complicated hereditary spastic paraplegia

por Bouwkamp, Christian G., Afawi, Zaid, Fattal-Valevski, Aviva, Krabbendam, Inge E., Rivetti, Stefano, Masalha, Rafik, Quadri, Marialuisa, Breedveld, Guido J., Mandel, Hanna, Tailakh, Muhammad Abu, Beverloo, H. Berna, Stevanin, Giovanni, Brice, Alexis, van IJcken, Wilfred F.J., Vernooij, Meike W., Dolga, Amalia M., de Vrij, Femke M.S., Bonifati, Vincenzo, Kushner, Steven A.
Publicado en Neurol Genet (2018)

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

por van Esbroeck, Annelot C.M., Janssen, Antonius P.A., Cognetta, Armand B., Ogasawara, Daisuke, Shpak, Guy, van der Kroeg, Mark, Kantae, Vasudev, Baggelaar, Marc P., de Vrij, Femke M.S., Deng, Hui, Allarà, Marco, Fezza, Filomena, Lin, Zhanmin, van der Wel, Tom, Soethoudt, Marjolein, Mock, Elliot D., den Dulk, Hans, Baak, Ilse L., Florea, Bogdan I., Hendriks, Giel, De Petrocellis, Luciano, Overkleeft, Herman S., Hankemeier, Thomas, De Zeeuw, Chris I., Di Marzo, Vincenzo, Maccarrone, Mauro, Cravatt, Benjamin F., Kushner, Steven A., van der Stelt, Mario
Publicado en Science (2017)

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia

por de Vrij, Femke M., Bouwkamp, Christian G., Gunhanlar, Nilhan, Shpak, Guy, Lendemeijer, Bas, Baghdadi, Maarouf, Gopalakrishna, Shreekara, Ghazvini, Mehrnaz, Li, Tracy M., Quadri, Marialuisa, Olgiati, Simone, Breedveld, Guido J., Coesmans, Michiel, Mientjes, Edwin, de Wit, Ton, Verheijen, Frans W., Beverloo, H. Berna, Cohen, Dan, Kok, Rob M., Bakker, P. Roberto, Nijburg, Aviva, Spijker, Annet T., Haffmans, P. M. Judith, Hoencamp, Erik, Bergink, Veerle, Vorstman, Jacob A., Wu, Timothy, Olde Loohuis, Loes M., Amin, Najaf, Langen, Carolyn D., Hofman, Albert, Hoogendijk, Witte J., van Duijn, Cornelia M., Ikram, M. Arfan, Vernooij, Meike W., Tiemeier, Henning, Uitterlinden, André G., Elgersma, Ype, Distel, Ben, Gribnau, Joost, White, Tonya, Bonifati, Vincenzo, Kushner, Steven A.
Publicado en Mol Psychiatry (2018)

Novel genetic loci affecting facial shape variation in humans

por Xiong, Ziyi, Dankova, Gabriela, Howe, Laurence J, Lee, Myoung Keun, Hysi, Pirro G, de Jong, Markus A, Zhu, Gu, Adhikari, Kaustubh, Li, Dan, Li, Yi, Pan, Bo, Feingold, Eleanor, Marazita, Mary L, Shaffer, John R, McAloney, Kerrie, Xu, Shu-Hua, Jin, Li, Wang, Sijia, de Vrij, Femke MS, Lendemeijer, Bas, Richmond, Stephen, Zhurov, Alexei, Lewis, Sarah, Sharp, Gemma C, Paternoster, Lavinia, Thompson, Holly, Gonzalez-Jose, Rolando, Bortolini, Maria Catira, Canizales-Quinteros, Samuel, Gallo, Carla, Poletti, Giovanni, Bedoya, Gabriel, Rothhammer, Francisco, Uitterlinden, André G, Ikram, M Arfan, Wolvius, Eppo, Kushner, Steven A, Nijsten, Tamar EC, Palstra, Robert-Jan TS, Boehringer, Stefan, Medland, Sarah E, Tang, Kun, Ruiz-Linares, Andres, Martin, Nicholas G, Spector, Timothy D, Stergiakouli, Evie, Weinberg, Seth M, Liu, Fan, Kayser, Manfred
Publicado en eLife (2019)

How the COVID-19 pandemic highlights the necessity of animal research

por Genzel, Lisa, Adan, Roger, Berns, Anton, van den Beucken, Jeroen J.J.P., Blokland, Arjan, Boddeke, Erik H.W.G.M., Bogers, Willy M., Bontrop, Ronald, Bulthuis, R., Bousema, Teun, Clevers, Hans, Coenen, Tineke C.J.J., van Dam, Anne-Marie, Deen, Peter M.T., van Dijk, K.W., Eggen, Bart J.L., Elgersma, Ype, Erdogan, Izel, Englitz, Bernhard, Fentener van Vlissingen, J. Martje, la Fleur, Susanne, Fouchier, Ron, Fitzsimons, Carlos P., Frieling, Wilbert, Haagmans, Bart, Heesters, Balthasar A., Henckens, Marloes J.A.G., Herfst, Sander, Hol, Elly, van den Hove, Daniel, de Jonge, Marien I., Jonkers, Jos, Joosten, Leo A.B., Kalsbeek, Andries, Kamermans, Maarten, Kampinga, Harm H., Kas, Martien J., Keijer, J.aap, Kersten, Sander, Kiliaan, Amanda J., Kooij, Taco W.A., Kooijman, Sander, Koopman, Werner J.H., Korosi, Aniko, Krugers, Harm J., Kuiken, Thijs, Kushner, Steven A., Langermans, Jan A.M., Lesscher, Heidi M.B., Lucassen, Paul J., Lutgens, Esther, Netea, Mihai G., Noldus, Lucas P.J.J., van der Meer, Jos W.M., Meye, Frank J., Mul, Joram D., van Oers, Kees, Olivier, Jocelien D.A., Pasterkamp, R. Jeroen, Philippens, Ingrid H.C.H.M., Prickaerts, Jos, Pollux, B.J.A., Rensen, Patrick C.N., van Rheenen, Jacco, van Rij, Ronald P., Ritsma, Laila, Rockx, Barry.H.G., Roozendaal, Benno, van Schothorst, Evert M., Stittelaar, K., Stockhofe, Norbert, Swaab, Dick F., de Swart, Rik L., Vanderschuren, Louk J.M.J., de Vries, Taco J., de Vrij, Femke, van Wezel, Richard, Wierenga, Corette J., Wiesmann, Maximilian, Willuhn, Ingo, de Zeeuw, Chris I., Homberg, Judith R.
Publicado en Curr Biol (2020)

How the COVID-19 pandemic highlights the necessity of animal research

por Genzel, Lisa, Adan, Roger, Berns, Anton, van den Beucken, Jeroen J.J.P., Blokland, Arjan, Boddeke, Erik H.W.G.M., Bogers, Willy M., Bontrop, Ronald, Bulthuis, R., Bousema, Teun, Clevers, Hans, Coenen, Tineke C.J.J., van Dam, Anne-Marie, Deen, Peter M.T., van Dijk, K.W., Eggen, Bart J.L., Elgersma, Ype, Erdogan, Izel, Englitz, Bernhard, Fentener van Vlissingen, J. Martje, la Fleur, Susanne, Fouchier, Ron, Fitzsimons, Carlos P., Frieling, Wilbert, Haagmans, Bart, Heesters, Balthasar A., Henckens, Marloes J.A.G., Herfst, Sander, Hol, Elly, van den Hove, Daniel, de Jonge, Marien I., Jonkers, Jos, Joosten, Leo A.B., Kalsbeek, Andries, Kamermans, Maarten, Kampinga, Harm H., Kas, Martien J., Keijer, Jaap, Kersten, Sander, Kiliaan, Amanda J., Kooij, Taco W.A., Kooijman, Sander, Koopman, Werner J.H., Korosi, Aniko, Krugers, Harm J., Kuiken, Thijs, Kushner, Steven A., Langermans, Jan A.M., Lesscher, Heidi M.B., Lucassen, Paul J., Lutgens, Esther, Netea, Mihai G., Noldus, Lucas P.J.J., van der Meer, Jos W.M., Meye, Frank J., Mul, Joram D., van Oers, Kees, Olivier, Jocelien D.A., Pasterkamp, R. Jeroen, Philippens, Ingrid H.C.H.M., Prickaerts, Jos, Pollux, B.J.A., Rensen, Patrick C.N., van Rheenen, Jacco, van Rij, Ronald P., Ritsma, Laila, Rockx, Barry.H.G., Roozendaal, Benno, van Schothorst, Evert M., Stittelaar, K., Stockhofe, Norbert, Swaab, Dick F., de Swart, Rik L., Vanderschuren, Louk J.M.J., de Vries, Taco J., de Vrij, Femke, van Wezel, Richard, Wierenga, Corette J., Wiesmann, Maximilian, Willuhn, Ingo, de Zeeuw, Chris I., Homberg, Judith R.
Publicado en Curr Biol (2020)