The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Presynaptic terminals are metabolically active and accrue damage through continuous vesicle cycling. How synapses locally regulate protein homeostasis is poorly understood. We show that the presynaptic lipid phosphatase synaptojanin is required for macroautophagy, and this role is inhibited by the P...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Vanhauwaert, Roeland, Kuenen, Sabine, Masius, Roy, Bademosi, Adekunle, Manetsberger, Julia, Schoovaerts, Nils, Bounti, Laura, Gontcharenko, Serguei, Swerts, Jef, Vilain, Sven, Picillo, Marina, Barone, Paolo, Munshi, Shashini T, de Vrij, Femke MS, Kushner, Steven A, Gounko, Natalia V, Mandemakers, Wim, Bonifati, Vincenzo, Meunier, Frederic A, Soukup, Sandra‐Fausia, Verstreken, Patrik
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430236/
https://ncbi.nlm.nih.gov/pubmed/28331029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695773
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