The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Presynaptic terminals are metabolically active and accrue damage through continuous vesicle cycling. How synapses locally regulate protein homeostasis is poorly understood. We show that the presynaptic lipid phosphatase synaptojanin is required for macroautophagy, and this role is inhibited by the P...

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Vydáno v:EMBO J
Hlavní autoři: Vanhauwaert, Roeland, Kuenen, Sabine, Masius, Roy, Bademosi, Adekunle, Manetsberger, Julia, Schoovaerts, Nils, Bounti, Laura, Gontcharenko, Serguei, Swerts, Jef, Vilain, Sven, Picillo, Marina, Barone, Paolo, Munshi, Shashini T, de Vrij, Femke MS, Kushner, Steven A, Gounko, Natalia V, Mandemakers, Wim, Bonifati, Vincenzo, Meunier, Frederic A, Soukup, Sandra‐Fausia, Verstreken, Patrik
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430236/
https://ncbi.nlm.nih.gov/pubmed/28331029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695773
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