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An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum

The directed differentiation of patient-derived induced pluripotent stem cells into cell-type specific neurons has inspired the development of therapeutic discovery for neurodegenerative diseases. Many forms of ataxia result from degeneration of cerebellar Purkinje cells, but thus far it has not bee...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Higuera, Gustavo A., Iaffaldano, Grazia, Bedar, Meiwand, Shpak, Guy, Broersen, Robin, Munshi, Shashini T., Dupont, Catherine, Gribnau, Joost, de Vrij, Femke M. S., Kushner, Steven A., De Zeeuw, Chris I.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562837/
https://ncbi.nlm.nih.gov/pubmed/28821816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09348-1
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