An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum

The directed differentiation of patient-derived induced pluripotent stem cells into cell-type specific neurons has inspired the development of therapeutic discovery for neurodegenerative diseases. Many forms of ataxia result from degeneration of cerebellar Purkinje cells, but thus far it has not bee...

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Udgivet i:Sci Rep
Main Authors: Higuera, Gustavo A., Iaffaldano, Grazia, Bedar, Meiwand, Shpak, Guy, Broersen, Robin, Munshi, Shashini T., Dupont, Catherine, Gribnau, Joost, de Vrij, Femke M. S., Kushner, Steven A., De Zeeuw, Chris I.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562837/
https://ncbi.nlm.nih.gov/pubmed/28821816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09348-1
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