Regulation of Intestinal Electroneutral Sodium Absorption and the Brush Border Na(+)/H(+) Exchanger (NHE3) by Intracellular Calcium

Por Zachos, Nicholas C., Kovbasnjuk, Olga, Donowitz, Mark
Publicado em 2009

Carbachol-Mediated Endocytosis of NHE3 Involves a Clathrin-Independent Mechanism Requiring Lipid Rafts and Cdc42

Por Zachos, Nicholas C., Alamelumangpuram, Bharath, Lee, Luke J., Wang, Peng, Kovbasnjuk, Olga
Publicado em 2014

PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells

Por Zachos, Nicholas C., Lee, Luke J., Kovbasnjuk, Olga, Li, Xuhang, Donowitz, Mark
Publicado em 2013

Human mini-guts: new insights into intestinal physiology and host–pathogen interactions

Por In, Julie G., Foulke-Abel, Jennifer, Estes, Mary K., Zachos, Nicholas C., Kovbasnjuk, Olga, Donowitz, Mark
Publicado no Nat Rev Gastroenterol Hepatol (2016)

NHERF family and NHE3 regulation

Por Donowitz, Mark, Cha, Boyoung, Zachos, Nicholas C, Brett, Christopher L, Sharma, Annu, Tse, C Ming, Li, Xuhang
Publicado em 2005

Regulation of Expression of Microvillus Membrane Proteins by Estrogen in Baboon Fetal Ovarian Oocytes

Por Zachos, Nicholas C., Burch, Marcia G., Billiar, Reinhart B., Li, Chunhua, Albrecht, Eugene D., Pepe, Gerald J.
Publicado em 2008

The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology

Por Yu, Huimin, Hasan, Nesrin M., In, Julie G., Estes, Mary K., Kovbasnjuk, Olga, Zachos, Nicholas C., Donowitz, Mark
Publicado no Annu Rev Physiol (2017)

Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

Por Alex, Philip, Zachos, Nicholas C., Nguyen, Thuan, Gonzales, Liberty, Chen, Tian E., Conklin, Laurie S., Centola, Michael, Li, Xuhang
Publicado em 2009

Elevated Calcium Acutely Regulates Dynamic Interactions of NHERF2 and NHE3 Proteins in Opossum Kidney (OK) Cell Microvilli

Por Zhu, Xinjun, Cha, Boyoung, Zachos, Nicholas C., Sarker, Rafiquel, Chakraborty, Molee, Chen, Tian-e, Kovbasnjuk, Olga, Donowitz, Mark
Publicado em 2011

Elevated Intracellular Calcium Stimulates NHE3 Activity by an IKEPP (NHERF4) Dependent Mechanism

Por Zachos, Nicholas C., Hodson, Caleb, Kovbasnjuk, Olga, Li, Xuhang, Thelin, William R., Cha, Boyoung, Milgram, Sharon, Donowitz, Mark
Publicado em 2008

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions

Por Noel, Gaelle, Baetz, Nicholas W., Staab, Janet F., Donowitz, Mark, Kovbasnjuk, Olga, Pasetti, Marcela F., Zachos, Nicholas C.
Publicado no Sci Rep (2017)

Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions

Por Noel, Gaelle, Baetz, Nicholas W., Staab, Janet F., Donowitz, Mark, Kovbasnjuk, Olga, Pasetti, Marcela F., Zachos, Nicholas C.
Publicado no Sci Rep (2017)

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

Por Foulke-Abel, Jennifer, In, Julie, Yin, Jianyi, Zachos, Nicholas C., Kovbasnjuk, Olga, Estes, Mary K., de Jonge, Hugo, Donowitz, Mark
Publicado no Gastroenterology (2015)

NHERF3 (PDZK1) Contributes to Basal and Calcium Inhibition of NHE3 Activity in Caco-2BBe Cells

Por Zachos, Nicholas C., Li, Xuhang, Kovbasnjuk, Olga, Hogema, Boris, Sarker, Rafiquel, Lee, Luke J., Li, Min, de Jonge, Hugo, Donowitz, Mark
Publicado em 2009

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

Por Zachos, Nicholas C., Kovbasnjuk, Olga, Foulke-Abel, Jennifer, In, Julie, Blutt, Sarah E., de Jonge, Hugo R., Estes, Mary K., Donowitz, Mark
Publicado no J Biol Chem (2016)

PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs

Por Cha, Boyoung, Yang, Jianbo, Singh, Varsha, Zachos, Nicholas C., Sarker, Rafiquel I., Chen, Tian-e, Chakraborty, Molee, Tse, Chung-Ming, Donowitz, Mark
Publicado no J Biol Chem (2017)

NHE3 regulatory complexes

Por Donowitz, Mark, Mohan, Sachin, Zhu, Cindy Xinjun, Chen, Tian-E, Lin, Rong, Cha, Boyoung, Zachos, Nicholas C., Murtazina, Rakhilya, Sarker, Rafiquel, Li, Xuhang
Publicado em 2009

Phospholipase C-γ Binds Directly to the Na(+)/H(+) Exchanger 3 and Is Required for Calcium Regulation of Exchange Activity

Por Zachos, Nicholas C., van Rossum, Damian B., Li, Xuhang, Caraveo, Gabriela, Sarker, Rafiquel, Cha, Boyoung, Mohan, Sachin, Desiderio, Stephen, Patterson, Randen L., Donowitz, Mark
Publicado em 2009

NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum

Por Murtazina, Rakhilya, Kovbasnjuk, Olga, Chen, Tian-E, Zachos, Nicholas C., Chen, Yeuping, Kocinsky, Hetal S., Hogema, Boris M., Seidler, Ursula, de Jonge, Hugo R., Donowitz, Mark
Publicado em 2011

NHERF2/NHERF3 Protein Heterodimerization and Macrocomplex Formation Are Required for the Inhibition of NHE3 Activity by Carbachol

Por Yang, Jianbo, Singh, Varsha, Chen, Tian-E, Sarker, Rafiquel, Xiong, Lishou, Cha, Boyoung, Jin, Shi, Li, Xuhang, Tse, C. Ming, Zachos, Nicholas C., Donowitz, Mark
Publicado em 2014