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Carbachol-Mediated Endocytosis of NHE3 Involves a Clathrin-Independent Mechanism Requiring Lipid Rafts and Cdc42

BACKGROUND: In intestinal epithelial cells, acute regulation of the brush border Na(+)/H(+) exchanger, NHE3, usually occurs by changes in endocytosis and/or exocytosis. Constitutive NHE3 endocytosis involves clathrin. Carbachol (CCH), which elevates intracellular Ca(2+) ([Ca(2+)](i)), decreases NHE3...

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Detalhes bibliográficos
Main Authors: Zachos, Nicholas C., Alamelumangpuram, Bharath, Lee, Luke J., Wang, Peng, Kovbasnjuk, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052452/
https://ncbi.nlm.nih.gov/pubmed/24713550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000358659
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