Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy

بواسطة Jiang, Xiaowei, Tomlinson, Ian P. M.
الحاوية / القاعدة Open Biol (2020)

Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer

بواسطة Cornish, Alex J., Tomlinson, Ian P.M., Houlston, Richard S.
الحاوية / القاعدة Mol Aspects Med (2019)

Colorectal Carcinomas Arising in the Hyperplastic Polyposis Syndrome Progress through the Chromosomal Instability Pathway

بواسطة Hawkins, Nicholas J., Gorman, Patricia, Tomlinson, Ian P. M., Bullpitt, Peter, Ward, Robyn L.
منشور في 2000

The effects of mutational processes and selection on driver mutations across cancer types

بواسطة Temko, Daniel, Tomlinson, Ian P. M., Severini, Simone, Schuster-Böckler, Benjamin, Graham, Trevor A.
الحاوية / القاعدة Nat Commun (2018)

Author Correction: The effects of mutational processes and selection on driver mutations across cancer types

بواسطة Temko, Daniel, Tomlinson, Ian P. M., Severini, Simone, Schuster-Böckler, Benjamin, Graham, Trevor A.
الحاوية / القاعدة Nat Commun (2020)

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer

بواسطة Tomlinson, Ian P. M., Houlston, Richard S., Montgomery, Grant W., Sieber, Oliver M., Dunlop, Malcolm G.
الحاوية / القاعدة Mutagenesis (2012)

What Can Be Learnt about Disease Progression in Breast Cancer Dormancy from Relapse Data?

بواسطة Willis, Lisa, Graham, Trevor A., Alarcón, Tomás, Alison, Malcolm R., Tomlinson, Ian P. M., Page, Karen M.
منشور في 2013

Missense Mutations in Fumarate Hydratase in Multiple Cutaneous and Uterine Leiomyomatosis and Renal Cell Cancer

بواسطة Alam, N. Afrina, Olpin, Simon, Rowan, Andrew, Kelsell, David, Leigh, Irene M., Tomlinson, Ian P. M., Weaver, Todd
منشور في 2005

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients

بواسطة Mäkinen, Netta, Heinonen, Hanna-Riikka, Moore, Shane, Tomlinson, Ian P.M., van der Spuy, Zephne M., Aaltonen, Lauri A.
منشور في 2011

Methylation changes in the TFAP2E promoter region are associated with BRAF mutation and poorer overall & disease free survival in colorectal cancer

بواسطة Beggs, Andrew D., Dilworth, Mark P., Domingo, Enric, Midgley, Rachel, Kerr, David, Tomlinson, Ian P.M., Middleton, Gary W.
الحاوية / القاعدة Oncoscience (2015)

Molecular Analysis of Phyllodes Tumors Reveals Distinct Changes in the Epithelial and Stromal Components

بواسطة Sawyer, Elinor J., Hanby, Andrew M., Ellis, Paul, Lakhani, Sunil R., Ellis, Ian O., Boyle, Sue, Tomlinson, Ian P. M.
منشور في 2000

Comprehensive Analysis of SMAD4 Mutations and Protein Expression in Juvenile Polyposis : Evidence for a Distinct Genetic Pathway and Polyp Morphology in SMAD4 Mutation Carriers

بواسطة Woodford-Richens, Kelly L., Rowan, Andrew J., Poulsom, Richard, Bevan, Stephen, Salovaara, Reijo, Aaltonen, Lauri A., Houlston, Richard S., Wright, Nicholas A., Tomlinson, Ian P. M.
منشور في 2001

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas

بواسطة Fearnhead, Nicola S., Wilding, Jennifer L., Winney, Bruce, Tonks, Susan, Bartlett, Sylvia, Bicknell, David C., Tomlinson, Ian P. M., Mortensen, Neil J. McC., Bodmer, Walter F.
منشور في 2004

Low-Penetrance Susceptibility Variants in Familial Colorectal Cancer

بواسطة Niittymäki, Iina, Kaasinen, Eevi, Tuupanen, Sari, Karhu, Auli, Järvinen, Heikki, Mecklin, Jukka-Pekka, Tomlinson, Ian P.M., Di Bernardo, Maria Chiara, Houlston, Richard S., Aaltonen, Lauri A.
منشور في 2010

Loss of Expression and Promoter Methylation of SLIT2 Are Associated with Sessile Serrated Adenoma Formation

بواسطة Beggs, Andrew D., Jones, Angela, Shepherd, Neil, Arnaout, Abed, Finlayson, Caroline, Abulafi, A. Muti, Morton, Dion G., Matthews, Glenn M., Hodgson, Shirley V., Tomlinson, Ian P. M.
منشور في 2013

Germline Mutations but Not Somatic Changes at the MYH Locus Contribute to the Pathogenesis of Unselected Colorectal Cancers

بواسطة Halford, Sarah E. R., Rowan, Andrew J., Lipton, Lara, Sieber, Oliver M., Pack, Kevin, Thomas, Huw J. W., Hodgson, Shirley V., Bodmer, Walter F., Tomlinson, Ian P. M.
منشور في 2003

The Stem Cell Marker CD133 Associates with Enhanced Colony Formation and Cell Motility in Colorectal Cancer

بواسطة Elsaba, Tarek M. A., Martinez-Pomares, Luisa, Robins, Adrian R., Crook, Simon, Seth, Rashmi, Jackson, Darryl, McCart, Amy, Silver, Andrew R., Tomlinson, Ian P. M., Ilyas, Mohammad
منشور في 2010

Chromosomal Instability Confers Intrinsic Multi-Drug Resistance

بواسطة Lee, Alvin J X, Endesfelder, David, Rowan, Andrew J, Walther, Axel, Birkbak, Nicolai J, Futreal, P Andrew, Downward, Julian, Szallasi, Zoltan, Tomlinson, Ian P M, Kschischo, Maik, Swanton, Charles
منشور في 2011

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

بواسطة Church, David N., Briggs, Sarah E.W., Palles, Claire, Domingo, Enric, Kearsey, Stephen J., Grimes, Jonathon M., Gorman, Maggie, Martin, Lynn, Howarth, Kimberley M., Hodgson, Shirley V., Kaur, Kulvinder, Taylor, Jenny, Tomlinson, Ian P.M.
منشور في 2013

Measuring single cell divisions in human tissues from multi-region sequencing data

بواسطة Werner, Benjamin, Case, Jack, Williams, Marc J., Chkhaidze, Ketevan, Temko, Daniel, Fernández-Mateos, Javier, Cresswell, George D., Nichol, Daniel, Cross, William, Spiteri, Inmaculada, Huang, Weini, Tomlinson, Ian P. M., Barnes, Chris P., Graham, Trevor A., Sottoriva, Andrea
الحاوية / القاعدة Nat Commun (2020)