Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas

Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibility to...

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Detalhes bibliográficos
Main Authors: Fearnhead, Nicola S., Wilding, Jennifer L., Winney, Bruce, Tonks, Susan, Bartlett, Sylvia, Bicknell, David C., Tomlinson, Ian P. M., Mortensen, Neil J. McC., Bodmer, Walter F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC528777/
https://ncbi.nlm.nih.gov/pubmed/15520370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407187101
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