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Common and rare variants in multifactorial susceptibility to common diseases
Here, we give a historical overview of the search for genetic variants that influence the susceptibility of an individual to a chronic disease, from RA Fisher's seminal work to the current excitement of whole-genome association studies (WGAS). We then discuss the concepts behind the identificat...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527050/ https://ncbi.nlm.nih.gov/pubmed/18509313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.f.136 |
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