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Are Rare Variants Responsible for Susceptibility to Complex Diseases?

Little is known about the nature of genetic variation underlying complex diseases in humans. One popular view proposes that mapping efforts should focus on identification of susceptibility mutations that are relatively old and at high frequency. It is generally assumed—at least for modeling purposes...

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Bibliografiske detaljer
Hovedforfatter: Pritchard, Jonathan K.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Human Genetics 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1226027/
https://ncbi.nlm.nih.gov/pubmed/11404818
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