Incremental value of rare genetic variants for the prediction of multifactorial diseases

BACKGROUND: It is often assumed that rare genetic variants will improve available risk prediction scores. We aimed to estimate the added predictive ability of rare variants for risk prediction of common diseases in hypothetical scenarios. METHODS: In simulated data, we constructed risk models with a...

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Hauptverfasser: Mihaescu, Raluca, Pencina, Michael J, Alonso, Alvaro, Lunetta, Kathryn L, Heckbert, Susan R, Benjamin, Emelia J, JW Janssens, A Cecile
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971349/
https://ncbi.nlm.nih.gov/pubmed/23961719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm480
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