Incremental value of rare genetic variants for the prediction of multifactorial diseases

BACKGROUND: It is often assumed that rare genetic variants will improve available risk prediction scores. We aimed to estimate the added predictive ability of rare variants for risk prediction of common diseases in hypothetical scenarios. METHODS: In simulated data, we constructed risk models with a...

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Detaylı Bibliyografya
Asıl Yazarlar: Mihaescu, Raluca, Pencina, Michael J, Alonso, Alvaro, Lunetta, Kathryn L, Heckbert, Susan R, Benjamin, Emelia J, JW Janssens, A Cecile
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971349/
https://ncbi.nlm.nih.gov/pubmed/23961719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm480
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