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Incremental value of rare genetic variants for the prediction of multifactorial diseases
BACKGROUND: It is often assumed that rare genetic variants will improve available risk prediction scores. We aimed to estimate the added predictive ability of rare variants for risk prediction of common diseases in hypothetical scenarios. METHODS: In simulated data, we constructed risk models with a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971349/ https://ncbi.nlm.nih.gov/pubmed/23961719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm480 |
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