Germline Mutations but Not Somatic Changes at the MYH Locus Contribute to the Pathogenesis of Unselected Colorectal Cancers

MYH-associated polyposis is a recently described, autosomal recessive condition comprising multiple colorectal adenomas and cancer. This disease is caused by germline mutations in the base excision repair (BER) gene MYH. Genes involved in the BER pathway are thus good candidates for involvement in t...

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Main Authors: Halford, Sarah E. R., Rowan, Andrew J., Lipton, Lara, Sieber, Oliver M., Pack, Kevin, Thomas, Huw J. W., Hodgson, Shirley V., Bodmer, Walter F., Tomlinson, Ian P. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851182/
https://ncbi.nlm.nih.gov/pubmed/12707038
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