Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin

Por Warn, Peter, Thommes, Pia, Sattar, Abdul, Corbett, David, Flattery, Amy, Zhang, Zuo, Black, Todd, Hernandez, Lorraine D., Therien, Alex G.
Publicado no Antimicrob Agents Chemother (2016)

Broad Coverage of Genetically Diverse Strains of Clostridium difficile by Actoxumab and Bezlotoxumab Predicted by In Vitro Neutralization and Epitope Modeling

Por Hernandez, Lorraine D., Racine, Fred, Xiao, Li, DiNunzio, Edward, Hairston, Nichelle, Sheth, Payal R., Murgolo, Nicholas J., Therien, Alex G.
Publicado no Antimicrob Agents Chemother (2015)

Gene expression profiling following <it>NRF2</it> and <it>KEAP1</it> siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

Por Fourtounis Jimmy, Wang I-Ming, Mathieu Marie-Claude, Claveau David, Loo Tenneille, Jackson Aimee L, Peters Mette A, Therien Alex G, Boie Yves, Crackower Michael A
Publicado em 2012-10-01

Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

Por Fourtounis, Jimmy, Wang, I-Ming, Mathieu, Marie-Claude, Claveau, David, Loo, Tenneille, Jackson, Aimee L, Peters, Mette A, Therien, Alex G, Boie, Yves, Crackower, Michael A
Publicado em 2012

Mechanisms of Protection against Clostridium difficile Infection by the Monoclonal Antitoxin Antibodies Actoxumab and Bezlotoxumab

Por Yang, Zhiyong, Ramsey, Jeremy, Hamza, Therwa, Zhang, Yongrong, Li, Shan, Yfantis, Harris G., Lee, Dong, Hernandez, Lorraine D., Seghezzi, Wolfgang, Furneisen, Jamie M., Davis, Nicole M., Therien, Alex G., Feng, Hanping
Publicado no Infect Immun (2015)

Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants

Por Gupta, Pulkit, Zhang, Zhifen, Sugiman-Marangos, Seiji N., Tam, John, Raman, Swetha, Julien, Jean-Phillipe, Kroh, Heather K., Lacy, D. Borden, Murgolo, Nicholas, Bekkari, Kavitha, Therien, Alex G., Hernandez, Lorraine D., Melnyk, Roman A.
Publicado no J Biol Chem (2017)

Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

Por Orth, Peter, Xiao, Li, Hernandez, Lorraine D., Reichert, Paul, Sheth, Payal R., Beaumont, Maribel, Yang, Xiaoyu, Murgolo, Nicholas, Ermakov, Grigori, DiNunzio, Edward, Racine, Fred, Karczewski, Jerzy, Secore, Susan, Ingram, Richard N., Mayhood, Todd, Strickland, Corey, Therien, Alex G.
Publicado em 2014

Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

Por Therien, Alex G., Huber, Joann L., Wilson, Kenneth E., Beaulieu, Patrick, Caron, Alexandre, Claveau, David, Deschamps, Kathleen, Donald, Robert G. K., Galgoci, Andrew M., Gallant, Michel, Gu, Xin, Kevin, Nancy J., Lafleur, Josiane, Leavitt, Penny S., Lebeau-Jacob, Christian, Lee, Suzy S., Lin, Molly M., Michels, Anna A., Ogawa, Aimie M., Painter, Ronald E., Parish, Craig A., Park, Young-Whan, Benton-Perdomo, Liliana, Petcu, Mihai, Phillips, John W., Powles, Mary Ann, Skorey, Kathryn I., Tam, John, Tan, Christopher M., Young, Katherine, Wong, Simon, Waddell, Sherman T., Miesel, Lynn
Publicado em 2012