Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT

Por Deane, Karen J., Summers, Robert L., Lehane, Adele M., Martin, Rowena E., Barrow, Russell A.
Publicado em 2014

Biochemical characterization and chemical inhibition of PfATP4-associated Na(+)-ATPase activity in Plasmodium falciparum membranes

Por Rosling, James E. O., Ridgway, Melanie C., Summers, Robert L., Kirk, Kiaran, Lehane, Adele M.
Publicado no J Biol Chem (2018)

Inferring a complete genotype-phenotype map from a small number of measured phenotypes

Por Sailer, Zachary R., Shafik, Sarah H., Summers, Robert L., Joule, Alex, Patterson-Robert, Alice, Martin, Rowena E., Harms, Michael J.
Publicado no PLoS Comput Biol (2020)

(1)H-NMR metabolite profiles of different strains of Plasmodium falciparum

Por Teng, Rongwei, Lehane, Adele M., Winterberg, Markus, Shafik, Sarah H., Summers, Robert L., Martin, Rowena E., van Schalkwyk, Donelly A., Junankar, Pauline R., Kirk, Kiaran
Publicado no Biosci Rep (2014)

Multiple Drugs Compete for Transport via the Plasmodium falciparum Chloroquine Resistance Transporter at Distinct but Interdependent Sites

Por Bellanca, Sebastiano, Summers, Robert L., Meyrath, Max, Dave, Anurag, Nash, Megan N., Dittmer, Martin, Sanchez, Cecilia P., Stein, Wilfred D., Martin, Rowena E., Lanzer, Michael
Publicado no J Biol Chem (2014)

The natural function of the malaria parasite’s chloroquine resistance transporter

Por Shafik, Sarah H., Cobbold, Simon A., Barkat, Kawthar, Richards, Sashika N., Lancaster, Nicole S., Llinás, Manuel, Hogg, Simon J., Summers, Robert L., McConville, Malcolm J., Martin, Rowena E.
Publicado no Nat Commun (2020)

Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum

Por Hrycyna, Christine A., Summers, Robert L., Lehane, Adele M., Pires, Marcos M., Namanja, Hilda, Bohn, Kelsey, Kuriakose, Jerrin, Ferdig, Michael, Henrich, Philipp P., Fidock, David A., Kirk, Kiaran, Chmielewski, Jean, Martin, Rowena E.
Publicado em 2014

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite’s chloroquine resistance transporter

Por Summers, Robert L., Dave, Anurag, Dolstra, Tegan J., Bellanca, Sebastiano, Marchetti, Rosa V., Nash, Megan N., Richards, Sashika N., Goh, Valerie, Schenk, Robyn L., Stein, Wilfred D., Kirk, Kiaran, Sanchez, Cecilia P., Lanzer, Michael, Martin, Rowena E.
Publicado em 2014