2-Hydroxyglutarate is not a metabolite; d-2-hydroxyglutarate and l-2-hydroxyglutarate are!

per Struys, Eduard A.
Publicat 2013

Progress in understanding 2-hydroxyglutaric acidurias

per Kranendijk, Martijn, Struys, Eduard A., Salomons, Gajja S., Van der Knaap, Marjo S., Jakobs, Cornelis
Publicat 2012

The measurement of urinary Δ(1)-piperideine-6-carboxylate, the alter ego of α-aminoadipic semialdehyde, in Antiquitin deficiency

per Struys, Eduard A., Bok, Levinus A., Emal, Dina, Houterman, Saskia, Willemsen, Michel A., Jakobs, Cornelis
Publicat 2012

A catabolic block does not sufficiently explain how 2-deoxy-d-glucose inhibits cell growth

per Ralser, Markus, Wamelink, Mirjam M., Struys, Eduard A., Joppich, Christian, Krobitsch, Sylvia, Jakobs, Cornelis, Lehrach, Hans
Publicat 2008

Ribose-5-Phosphate Isomerase Deficiency: New Inborn Error in the Pentose Phosphate Pathway Associated with a Slowly Progressive Leukoencephalopathy

per Huck, Jojanneke H. J., Verhoeven, Nanda M., Struys, Eduard A., Salomons, Gajja S., Jakobs, Cornelis, van der Knaap, Marjo S.
Publicat 2004

Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming

per Prigione, Alessandro, Lichtner, Björn, Kuhl, Heiner, Struys, Eduard A., Wamelink, Mirjam, Lehrach, Hans, Ralser, Markus, Timmermann, Bernd, Adjaye, James
Publicat a Stem Cells (2014)

Mutations in the d-2-Hydroxyglutarate Dehydrogenase Gene Cause d-2-Hydroxyglutaric Aciduria

per Struys, Eduard A., Salomons, Gajja S., Achouri, Younes, Van Schaftingen, Emile, Grosso, Salvatore, Craigen, William J., Verhoeven, Nanda M., Jakobs, Cornelis
Publicat 2005

Guanidinoacetate Methyltransferase Activity in Lymphocytes, for a Fast Diagnosis

per Berends, Lisette M., Struys, Eduard A., Roos, Birthe, Holwerda, Ulbe, Jansen, Erwin E. W., Salomons, Gajja S., Wamelink, Mirjam M. C.
Publicat a JIMD Rep (2017)

Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4(+) T Cells

per Hegedus, Andrea, Kavanagh Williamson, Maia, Khan, Mariam B., Dias Zeidler, Julianna, Da Poian, Andrea T., El-Bacha, Tatiana, Struys, Eduard A., Huthoff, Hendrik
Publicat a AIDS Res Hum Retroviruses (2017)

No evidence for cell‐to‐cell transmission of the unfolded protein response in cell culture

per van Ziel, Anna M., Wolzak, Kimberly, Nölle, Anna, Hoetjes, Petrus J., Berenjeno‐Correa, Ernesto, van Anken, Eelco, Struys, Eduard A., Scheper, Wiep
Publicat a J Neurochem (2019)

Transaldolase Deficiency: Liver Cirrhosis Associated with a New Inborn Error in the Pentose Phosphate Pathway

per Verhoeven, Nanda M., Huck, Jojanneke H. J., Roos, Birthe, Struys, Eduard A., Salomons, Gajja S., Douwes, Adriaan C., van der Knaap, Marjo S., Jakobs, Cornelis
Publicat 2001

Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

per Ralser, Markus, Wamelink, Mirjam M, Kowald, Axel, Gerisch, Birgit, Heeren, Gino, Struys, Eduard A, Klipp, Edda, Jakobs, Cornelis, Breitenbach, Michael, Lehrach, Hans, Krobitsch, Sylvia
Publicat 2007

Frequent reconstitution of IDH2(R140Q) mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia

per Wiseman, Daniel H., Williams, Emma L., Wilks, Deepti P., Sun Leong, Hui, Somerville, Tim D. D., Dennis, Michael W., Struys, Eduard A., Bakkali, Abdellatif, Salomons, Gajja S., Somervaille, Tim C. P.
Publicat a Leukemia (2016)

IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis

per Gao, Ya, de Wit, Maurice, Struys, Eduard A., van der Linde, Herma C. Z., Salomons, Gajja S., Lamfers, Martine L. M., Willemsen, Rob, Sillevis Smitt, Peter A. E., French, Pim J.
Publicat a PLoS One (2018)

A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors

per Khurshed, Mohammed, Molenaar, Remco J., van Linde, Myra E., Mathôt, Ron A., Struys, Eduard A., van Wezel, Tom, van Noorden, Cornelis J. F., Klümpen, Heinz-Josef, Bovée, Judith V. M. G., Wilmink, Johanna W.
Publicat a Cancers (Basel) (2021)

In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site

per Chaturvedi, Anuhar, Goparaju, Ramya, Gupta, Charu, Weder, Julia, Klünemann, Thomas, Araujo Cruz, Michelle Maria, Kloos, Arnold, Goerlich, Kerstin, Schottmann, Renate, Othman, Basem, Struys, Eduard A., Bähre, Heike, Grote-Koska, Denis, Brand, Korbinian, Ganser, Arnold, Preller, Matthias, Heuser, Michael
Publicat a Leukemia (2019)

Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate

per Chaturvedi, Anuhar, Araujo Cruz, Michelle Maria, Jyotsana, Nidhi, Sharma, Amit, Goparaju, Ramya, Schwarzer, Adrian, Görlich, Kerstin, Schottmann, Renate, Struys, Eduard A., Jansen, Erwin E., Rohde, Christian, Müller-Tidow, Carsten, Geffers, Robert, Göhring, Gudrun, Ganser, Arnold, Thol, Felicitas, Heuser, Michael
Publicat a Leukemia (2016)

TM-04 A TRANSGENIC ZEBRAFISH MODEL FOR GLIOMAS WITH MUTATIONS IN ISOCITRATE DEHYDROGENASE 1

per Gao, Ya D., van der Linde, Herma C. Z., Struys, Eduard A., van Breugel, Valeska, de Wit, Maurice, Erdem, Lale, Bovée, Judith V.M.G., Lamfers, Martine L. M., Silleviss Smitt, Peter A.E., Salomons, Gajja S., Willemsen, Rob, French, Pim J.
Publicat a Neuro Oncol (2014)

D‐2‐hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants

per Pop, Ana, Struys, Eduard A., Jansen, Erwin E. W., Fernandez, Matilde R., Kanhai, Warsha A., van Dooren, Silvy J. M., Ozturk, Senay, van Oostendorp, Justin, Lennertz, Pascal, Kranendijk, Martijn, van der Knaap, Marjo S., Gibson, K. Michael, van Schaftingen, Emile, Salomons, Gajja S.
Publicat a Hum Mutat (2019)

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

per Suijker, Johnny, Oosting, Jan, Koornneef, Annemarie, Struys, Eduard A., Salomons, Gajja S., Schaap, Frank G., Waaijer, Cathelijn J.F., Wijers-Koster, Pauline M., Briaire-de Bruijn, Inge H., Haazen, Lizette, Riester, Scott M., Dudakovic, Amel, Danen, Erik, Cleton-Jansen, Anne-Marie, van Wijnen, Andre J., Bovée, Judith V.M.G.
Publicat a Oncotarget (2015)