Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

Por Murray-Stewart, Tracy
Publicado em 2019

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines

Por Murray-Stewart, Tracy, Woster, Patrick M., Casero, Robert A.
Publicado em 2013

Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression.

Por Wang, Yanlin, Devereux, Wendy, Stewart, Tracy M, Casero, Robert A
Publicado em 2002

Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics.

Por Murray-Stewart, Tracy, Wang, Yanlin, Devereux, Wendy, Casero, Robert A
Publicado em 2002

A Simple Assay for Mammalian Spermine Oxidase: A Polyamine Catabolic Enzyme Implicated in Drug Response and Disease

Por Goodwin, Andrew C., Murray-Stewart, Tracy R., Casero, Robert A.
Publicado em 2011

Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention

Por Battaglia, Valentina, Shields, Christina DeStefano, Murray-Stewart, Tracy, Casero, Robert A.
Publicado em 2013

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes

Por Wu, Yu, Steinbergs, Nora, Murray-Stewart, Tracy, Marton, Laurence J., Casero, Robert A.
Publicado em 2012

Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology

Por Murray-Stewart, Tracy, Wang, Yanlin, Goodwin, Andrew, Hacker, Amy, Meeker, Alan, Casero, Robert A.
Publicado em 2008

Polyamine Catabolism Is Enhanced after Traumatic Brain Injury

Por Zahedi, Kamyar, Huttinger, Francis, Morrison, Ryan, Murray-Stewart, Tracy, Casero, Robert A., Strauss, Kenneth I.
Publicado em 2010

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism

Por Murray-Stewart, Tracy, Hanigan, Christin L., Woster, Patrick M., Marton, Laurence J., Casero, Robert A.
Publicado em 2013

Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein

Por Wang, Yanlin, Hacker, Amy, Murray-Stewart, Tracy, Fleischer, Jennifer G., Woster, Patrick M., Casero, Robert A.
Publicado em 2005

Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct.

Por Murray-Stewart, Tracy, Applegren, Nancy B, Devereux, Wendy, Hacker, Amy, Smith, Renee, Wang, Yanlin, Casero, Robert A
Publicado em 2003

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047

Por Murray-Stewart, Tracy, Ferrari, Elena, Xie, Ying, Yu, Fei, Marton, Laurence J., Oupicky, David, Casero, Robert A.
Publicado no PLoS One (2017)

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

Por Huang, Yi, Greene, Eriko, Murray Stewart, Tracy, Goodwin, Andrew C., Baylin, Stephen B., Woster, Patrick M., Casero, Robert A.
Publicado em 2007

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy

Por Xie, Ying, Murray-Stewart, Tracy, Wang, Yazhe, Yu, Fei, Li, Jing, Marton, Laurence J., Casero, Robert A., Oupický, David
Publicado no J Control Release (2016)

Proximal Tubule Epithelial Cell Specific Ablation of the Spermidine/Spermine N(1)-Acetyltransferase Gene Reduces the Severity of Renal Ischemia/Reperfusion Injury

Por Zahedi, Kamyar, Barone, Sharon, Wang, Yang, Murray-Stewart, Tracy, Roy-Chaudhury, Prabir, Smith, Roger D., Casero, Robert A., Soleimani, Manoocher
Publicado no PLoS One (2014)

A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality

Por Mann, Val, Hobson, Emma E., Li, Baohua, Stewart, Tracy L., Grant, Struan F.A., Robins, Simon P., Aspden, Richard M., Ralston, Stuart H.
Publicado em 2001

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection

Por Hardbower, Dana M., Asim, Mohammad, Murray-Stewart, Tracy, Casero, Robert A., Verriere, Thomas, Lewis, Nuruddeen D., Chaturvedi, Rupesh, Piazuelo, M. Blanca, Wilson, Keith T.
Publicado no Amino Acids (2016)

Novel oligoamine analogues inhibit lysine-specific demethylase 1 (LSD1) and induce re-expression of epigenetically silenced genes

Por Huang, Yi, Stewart, Tracy Murray, Wu, Yu, Baylin, Stephen B., Marton, Laurence J., Perkins, Brandy, Jones, Richard J., Woster, Patrick M., Casero, Robert A.
Publicado em 2009

Epigenetic silencing of miR-124 prevents spermine oxidase regulation: Implications for Helicobacter pylori-induced gastric cancer

Por Murray-Stewart, Tracy, Sierra, Johanna C., Piazuelo, M. Blanca, Mera, Robertino M., Chaturvedi, Rupesh, Bravo, Luis E., Correa, Pelayo, Schneider, Barbara G., Wilson, Keith T., Casero, Robert A.
Publicado no Oncogene (2016)