Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

Epigenetic chromatin modification is a major regulator of eukaryotic gene expression, and aberrant epigenetic silencing of gene expression contributes to tumorigenesis. Histone modifications include acetylation, phosphorylation, and methylation, resulting in a combination of histone marks known coll...

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Bibliographische Detailangaben
Hauptverfasser: Huang, Yi, Greene, Eriko, Murray Stewart, Tracy, Goodwin, Andrew C., Baylin, Stephen B., Woster, Patrick M., Casero, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857229/
https://ncbi.nlm.nih.gov/pubmed/17463086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700720104
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