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Polyamine analogues modulate gene expression by inhibiting Lysine-Specific Demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells

Aberrant epigenetic repression of gene expression has been implicated in most cancers, including breast cancer. The nuclear amine oxidase, lysine-specific demethylase 1 (LSD1) has the ability to broadly repress gene expression by removing the activating mono- and di-methylation marks at the lysine 4...

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Bibliografiske detaljer
Main Authors: Zhu, Qingsong, Huang, Yi, Marton, Laurence J., Woster, Patrick M., Davidson, Nancy E., Casero, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240695/
https://ncbi.nlm.nih.gov/pubmed/21805138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-011-1004-1
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