Role of p53/p21 (Waf1/Cip1) in the Regulation of Polyamine Analogue-Induced Growth Inhibition and Cell Death in Human Breast Cancer Cells

Intracellular polyamines are absolutely required for cell proliferation and many tumors have abnormal requirements for polyamines. Therefore, the polyamine metabolic pathway represents a rational target for antineoplastic intervention. A number of polyamine analogues act as potent modulators of cell...

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Hauptverfasser: Huang, Yi, Pledgie, Allison, Rubin, Ethel, Marton, Laurence J., Woster, Patrick M., Sukumar, Saraswati, Casero, Robert A., Davidson, Nancy E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639297/
https://ncbi.nlm.nih.gov/pubmed/16131835
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