Molecules for the millennium: how will they look? New drug discovery year 2000

por Sausville, E A, Johnson, J I
Publicado 2000

Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line.

por Trepel, J B, Moyer, J D, Heikkila, R, Sausville, E A
Publicado 1988

Transcriptional activation and DNase I hypersensitive sites are associated with selective expression of the gastrin-releasing peptide gene.

por Markowitz, S, Krystal, G, Lebacq-Verheyden, A M, Way, J, Sausville, E A, Battey, J
Publicado 1988

Cholera toxin inhibits signal transduction by several mitogens and the in vitro growth of human small-cell lung cancer.

por Viallet, J, Sharoni, Y, Frucht, H, Jensen, R T, Minna, J D, Sausville, E A
Publicado 1990

P21-dependent G (1) arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

por Sandor, V, Senderowicz, A, Mertins, S, Sackett, D, Sausville, E, Blagosklonny, M V, Bates, S E
Publicado 2000

L-myc cooperates with ras to transform primary rat embryo fibroblasts.

por Birrer, M J, Segal, S, DeGreve, J S, Kaye, F, Sausville, E A, Minna, J D
Publicado 1988

Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer.

por Krystal, G, Birrer, M, Way, J, Nau, M, Sausville, E, Thompson, C, Minna, J, Battey, J
Publicado 1988

Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci.

por Kaye, F J, McBride, O W, Battey, J F, Gazdar, A F, Sausville, E A
Publicado 1987

In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles

por Bradshaw, T D, Chua, M-S, Browne, H L, Trapani, V, Sausville, E A, Stevens, M F G
Publicado 2002

The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs.

por De Greve, J, Battey, J, Fedorko, J, Birrer, M, Evan, G, Kaye, F, Sausville, E, Minna, J
Publicado 1988

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

por De Azevedo, W F, Mueller-Dieckmann, H J, Schulze-Gahmen, U, Worland, P J, Sausville, E, Kim, S H
Publicado 1996

Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing.

por Kaye, F, Battey, J, Nau, M, Brooks, B, Seifter, E, De Greve, J, Birrer, M, Sausville, E, Minna, J
Publicado 1988

Human small-cell lung cancers show amplification and expression of the N-myc gene.

por Nau, M M, Brooks, B J, Carney, D N, Gazdar, A F, Battey, J F, Sausville, E A, Minna, J D
Publicado 1986

Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.

por Trepel, J B, Colamonici, O R, Kelly, K, Schwab, G, Watt, R A, Sausville, E A, Jaffe, E S, Neckers, L M
Publicado 1987

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.

por Patel, V, Senderowicz, A M, Pinto, D, Igishi, T, Raffeld, M, Quintanilla-Martinez, L, Ensley, J F, Sausville, E A, Gutkind, J S
Publicado 1998

Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles.

por Turpin, J A, Terpening, S J, Schaeffer, C A, Yu, G, Glover, C J, Felsted, R L, Sausville, E A, Rice, W G
Publicado 1996

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

por Johnson, J I, Decker, S, Zaharevitz, D, Rubinstein, L V, Venditti, J M, Schepartz, S, Kalyandrug, S, Christian, M, Arbuck, S, Hollingshead, M, Sausville, E A
Publicado 2001

Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.

por Kitada, S., Krajewska, M., Zhang, X., Scudiero, D., Zapata, J. M., Wang, H. G., Shabaik, A., Tudor, G., Krajewski, S., Myers, T. G., Johnson, G. S., Sausville, E. A., Reed, J. C.
Publicado 1998

DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

por Trapani, V, Patel, V, Leong, C-O, Ciolino, H P, Yeh, G C, Hose, C, Trepel, J B, Stevens, M F G, Sausville, E A, Loaiza-Pérez, A I
Publicado 2003