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In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles

Novel 2-(4-aminophenyl)benzothiazoles possess highly selective, potent antitumour properties in vitro and in vivo. They induce and are biotransformed by cytochrome P450 (CYP) 1A1 to putative active as well as inactive metabolites. Metabolic inactivation of the molecule has been thwarted by isosteric...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Bradshaw, T D, Chua, M-S, Browne, H L, Trapani, V, Sausville, E A, Stevens, M F G
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2002
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375326/
https://ncbi.nlm.nih.gov/pubmed/11953897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600225
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