Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo

2-(4-Aminophenyl)benzothiazoles represent a potent and highly selective class of antitumour agent. In vitro, sensitive carcinoma cells deplete 2-(4-aminophenyl)benzothiazoles from nutrient media; cytochrome P450 1A1 activity, critical for execution of antitumour activity, and protein expression are...

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Main Authors: Leong, C-O, Gaskell, M, Martin, E A, Heydon, R T, Farmer, P B, Bibby, M C, Cooper, P A, Double, J A, Bradshaw, T D, Stevens, M F G
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2003
Ábhair:
Experimental Therapeutics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747538/
https://ncbi.nlm.nih.gov/pubmed/12569393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600719
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