Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity

All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of resistance, believed to be caused by increased all...

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Detalhes bibliográficos
Main Authors: Van heusden, J, Van Ginckel, R, Bruwiere, H, Moelans, P, Janssen, B, Floren, W, van der Leede, B J, van Dun, J, Sanz, G, Venet, M, Dillen, L, Van Hove, C, Willemsens, G, Janicot, M, Wouters, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375285/
https://ncbi.nlm.nih.gov/pubmed/11870544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600056
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