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Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity
All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of resistance, believed to be caused by increased all...
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| Главные авторы: | , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2375285/ https://ncbi.nlm.nih.gov/pubmed/11870544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600056 |
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