Atypical Protein Kinase C in Cardiometabolic Abnormalities

Por Farese, Robert V., Sajan, Mini P.
Publicado em 2012

Metabolic functions of atypical protein kinase C: “good” and “bad” as defined by nutritional status

Por Farese, Robert V., Sajan, Mini P.
Publicado em 2010

Meformin action in human hepatocytes. Co-activation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression

Por Sajan, Mini P., Ivey, Robert A., Farese, Robert V.
Publicado em 2013

Requirements for Pseudosubstrate Arginine Residues during Autoinhibition and Phosphatidylinositol 3,4,5-(PO(4))(3)-dependent Activation of Atypical PKC

Por Ivey, Robert A., Sajan, Mini P., Farese, Robert V.
Publicado em 2014

Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus

Por Farese, Robert V., Lee, Mackenzie C., Sajan, Mini P.
Publicado no J Clin Med (2014)

BMI-Related Progression of Atypical PKC-dependent Aberrations in Insulin Signaling Through IRS-1, Akt, FoxO1 and PGC-1α in Livers of Obese and Type 2 Diabetic Humans

Por Sajan, Mini P, Ivey, Robert A, Farese, Robert V
Publicado no Metabolism (2015)

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Por Sajan, Mini P., Ivey, Robert A., Lee, Mackenzie C., Farese, Robert V.
Publicado no J Lipid Res (2015)

Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscl...

Por Richter, Erik A, Vistisen, Bodil, Maarbjerg, Stine J, Sajan, Mini, Farese, Robert V, Kiens, Bente
Publicado em 2004

Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhance...

Por Sajan, Mini P, Jurzak, Michael J, Samuels, Varman T, Shulman, Gerald I, Braun, Ursula, Leitges, Michael, Farese, Robert V
Publicado em 2014

Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

Por Sajan, Mini P., Acevedo-Duncan, Mildred E., Standaert, Mary L., Ivey, Robert A., Lee, Mackenzie, Farese, Robert V.
Publicado em 2014

Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulate...

Por Sajan, Mini P, Bandyopadhyay, Gautam, Kanoh, Yoshinori, Standaert, Mary L, Quon, Michael J, Reed, Brent C, Dikic, Ivan, Farese, Robert V
Publicado em 2002

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

Por Sajan, Mini P., Standaert, Mary L., Nimal, Sonali, Varanasi, Usha, Pastoor, Tina, Mastorides, Stephen, Braun, Ursula, Leitges, Michael, Farese, Robert V.
Publicado em 2009

Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats

Por Sharma, Naveen, Arias, Edward B., Sajan, Mini P., MacKrell, James G., Bhat, Abhijit D., Farese, Robert V., Cartee, Gregory D.
Publicado em 2010

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ(1–40/42) and Phospho-Tau May Abet Alzheimer Development

Por Sajan, Mini, Hansen, Barbara, Ivey, Robert, Sajan, Joshua, Ari, Csilla, Song, Shijie, Braun, Ursula, Leitges, Michael, Farese-Higgs, Margaret, Farese, Robert V.
Publicado no Diabetes (2016)

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

Por Guo, Shaodong, Copps, Kyle D., Dong, Xiaocheng, Park, Sunmin, Cheng, Zhiyong, Pocai, Alessandro, Rossetti, Luciano, Sajan, Mini, Farese, Robert V., White, Morris F.
Publicado em 2009

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι

Por Sajan, Mini P., Nimal, Sonali, Mastorides, Stephen, Acevedo-Duncan, Mildred, Kahn, C. Ronald, Fields, Alan P., Braun, Ursula, Leitges, Michael, Farese, Robert V.
Publicado em 2012

Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal...

Por Frøsig, Christian, Sajan, Mini P, Maarbjerg, Stine J, Brandt, Nina, Roepstorff, Carsten, Wojtaszewski, Jørgen F P, Kiens, Bente, Farese, Robert V, Richter, Erik A
Publicado em 2007

Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats

Por Sharma, Naveen, Arias, Edward B., Bhat, Abhijit D., Sequea, Donel A., Ho, Steve, Croff, Kelsey K., Sajan, Mini P., Farese, Robert V., Cartee, Gregory D.
Publicado em 2011

PKCλ Haploinsufficiency Prevents Diabetes by a Mechanism Involving Alterations in Hepatic Enzymes

Por Sajan, Mini P., Ivey, Robert A., Lee, Mackenzie, Mastorides, Stephen, Jurczak, Michael J., Samuels, Varman T., Shulman, Gerald I., Braun, Ursula, Leitges, Michael, Farese, Robert V.
Publicado em 2014

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ(1–40/42) and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activ...

Por Sajan, Mini P., Hansen, Barbara C., Higgs, Margaret G., Kahn, C. Ron, Braun, Ursula, Leitges, Michael, Park, Collin R., Diamond, David M., Farese, Robert V.
Publicado no Neurobiol Aging (2017)