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Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which selectively impairs protein kinase B (Akt)-dependent...

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Pubblicato in:J Lipid Res
Autori principali: Sajan, Mini P., Ivey, Robert A., Lee, Mackenzie C., Farese, Robert V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274073/
https://ncbi.nlm.nih.gov/pubmed/25395359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M052977
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