The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

We used a Cre-loxP approach to generate mice with varied expression of hepatic Irs1 and Irs2 to establish the contribution of each protein to hepatic nutrient homeostasis. While nutrient-sensitive transcripts were expressed nearly normally in liver lacking Irs2 (LKO2 mice), these transcripts were si...

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Detalhes bibliográficos
Principais autores: Guo, Shaodong, Copps, Kyle D., Dong, Xiaocheng, Park, Sunmin, Cheng, Zhiyong, Pocai, Alessandro, Rossetti, Luciano, Sajan, Mini, Farese, Robert V., White, Morris F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738277/
https://ncbi.nlm.nih.gov/pubmed/19596788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00138-09
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