Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.

Sorbitol, "osmotic stress", stimulates GLUT4 glucose transporter translocation to the plasma membrane and glucose transport by a phosphatidylinositol (PI) 3-kinase-independent mechanism that reportedly involves non-receptor proline-rich tyrosine kinase-2 (PYK2) but subsequent events are ob...

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Bibliographische Detailangaben
Hauptverfasser: Sajan, Mini P, Bandyopadhyay, Gautam, Kanoh, Yoshinori, Standaert, Mary L, Quon, Michael J, Reed, Brent C, Dikic, Ivan, Farese, Robert V
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222431/
https://ncbi.nlm.nih.gov/pubmed/11879194
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