Genetics of idiopathic inflammatory myopathies: insights into disease pathogenesis

Por Rothwell, Simon, Chinoy, Hector, Lamb, Janine A.
Publicado no Curr Opin Rheumatol (2019)

Genetics in inclusion body myositis

Por Rothwell, Simon, Lilleker, James B., Lamb, Janine A.
Publicado no Curr Opin Rheumatol (2017)

The Ca(V)β Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel Ca(V)2.2 from Proteasomal Degradation but Not Oligoubiquitination

Por Page, Karen M., Rothwell, Simon W., Dolphin, Annette C.
Publicado no J Biol Chem (2016)

Strategies for Evaluating Idiopathic Inflammatory Myopathy Disease Susceptibility Genes

Por Rothwell, Simon, Cooper, Robert G., Lamb, Janine A., Chinoy, Hector
Publicado no Curr Rheumatol Rep (2014)

Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis

Por Parkes, Joanna E., Rothwell, Simon, Oldroyd, Alexander, Chinoy, Hector, Lamb, Janine A.
Publicado no Arthritis Res Ther (2018)

Direct Gating of ATP-activated Ion Channels (P2X2 Receptors) by Lipophilic Attachment at the Outer End of the Second Transmembrane Domain

Por Rothwell, Simon W., Stansfeld, Phillip J., Bragg, Laricia, Verkhratsky, Alexej, North, R. Alan
Publicado em 2014

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α(2)δ-1 subunit

Por Kadurin, Ivan, Rothwell, Simon W., Lana, Beatrice, Nieto-Rostro, Manuela, Dolphin, Annette C.
Publicado no Sci Rep (2017)

P2X(7)R activation drives distinct IL-1 responses in dendritic cells compared to macrophages

Por Englezou, Pavlos C., Rothwell, Simon W., Ainscough, Joseph S., Brough, David, Landsiedel, Robert, Verkhratsky, Alexei, Kimber, Ian, Dearman, Rebecca J.
Publicado no Cytokine (2015)

Searching for “monogenic diabetes” in dogs using a candidate gene approach

Por Short, Andrea D, Holder, Angela, Rothwell, Simon, Massey, Jonathan, Scholey, Rachel, Kennedy, Lorna J, Catchpole, Brian, Ollier, William ER
Publicado no Canine Genet Epidemiol (2014)

Association of an MHC Class II Haplotype with Increased Risk of Polymyositis in Hungarian Vizsla Dogs

Por Massey, Jonathan, Rothwell, Simon, Rusbridge, Clare, Tauro, Anna, Addicott, Diane, Chinoy, Hector, Cooper, Robert G., Ollier, William E. R., Kennedy, Lorna J.
Publicado em 2013

Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies

Por Parkes, Joanna E., Rothwell, Simon, Day, Philip J., McHugh, Neil J., Betteridge, Zoë E., Cooper, Robert G., Ollier, William E., Chinoy, Hector, Lamb, Janine A.
Publicado no Arthritis Res Ther (2016)

Proteolytic maturation of α(2)δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

Por Kadurin, Ivan, Ferron, Laurent, Rothwell, Simon W, Meyer, James O, Douglas, Leon R, Bauer, Claudia S, Lana, Beatrice, Margas, Wojciech, Alexopoulos, Orpheas, Nieto-Rostro, Manuela, Pratt, Wendy S, Dolphin, Annette C
Publicado no eLife (2016)

Disruption of the Key Ca(2+) Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking

Por Meyer, James O., Dahimene, Shehrazade, Page, Karen M., Ferron, Laurent, Kadurin, Ivan, Ellaway, Joseph I.J., Zhao, Pengxiang, Patel, Tarun, Rothwell, Simon W., Lin, Peipeng, Pratt, Wendy S., Dolphin, Annette C.
Publicado no Cell Rep (2019)

The myositis clinical phenotype associated with anti-Zo autoantibodies: a case series of nine UK patients

Por Tansley, Sarah L, Betteridge, Zoe, Lu, Hui, Davies, Emma, Rothwell, Simon, New, Paul P, Chinoy, Hector, Gordon, Patrick, Gunawardena, Harsha, Lloyd, Mark, Stratton, Richard, Cooper, Robert, McHugh, Neil J
Publicado no Rheumatology (Oxford) (2020)

Dense Genotyping of Immune-Related Loci in the Idiopathic Inflammatory Myopathies Confirms HLA alleles as Strongest Genetic Risk Factor and Suggests Different Genetic Background fo...

Por Rothwell, Simon, Cooper, Robert G., Lundberg, Ingrid E., Miller, Frederick W., Gregersen, Peter K., Bowes, John, Vencovsky, Jiri, Danko, Katalin, Limaye, Vidya, Selva-O’Callaghan, Albert, Hanna, Michael G., Machado, Pedro M., Pachman, Lauren M., Reed, Ann M., Rider, Lisa G., Cobb, Joanna, Platt, Hazel, Molberg, Øyvind, Benveniste, Olivier, Mathiesen, Pernille, Radstake, Timothy, Doria, Andrea, De Bleecker, Jan, De Paepe, Boel, Maurer, Britta, Ollier, William E., Padyukov, Leonid, O’Hanlon, Terrance P., Lee, Annette, Amos, Christopher I., Gieger, Christian, Meitinger, Thomas, Winkelmann, Juliane, Wedderburn, Lucy R, Chinoy, Hector, Lamb, Janine A
Publicado no Ann Rheum Dis (2015)

Immune‐Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA–DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum

Por Rothwell, Simon, Cooper, Robert G., Lundberg, Ingrid E., Gregersen, Peter K., Hanna, Michael G., Machado, Pedro M., Herbert, Megan K., Pruijn, Ger J. M., Lilleker, James B., Roberts, Mark, Bowes, John, Seldin, Michael F., Vencovsky, Jiri, Danko, Katalin, Limaye, Vidya, Selva‐O'Callaghan, Albert, Platt, Hazel, Molberg, Øyvind, Benveniste, Olivier, Radstake, Timothy R. D. J., Doria, Andrea, De Bleecker, Jan, De Paepe, Boel, Gieger, Christian, Meitinger, Thomas, Winkelmann, Juliane, Amos, Christopher I., Ollier, William E., Padyukov, Leonid, Lee, Annette T., Lamb, Janine A., Chinoy, Hector, Denton, Christopher, Gheorghe, Karina, Hilton‐Jones, David, Kiely, Patrick, Mann, Herman
Publicado no Arthritis Rheumatol (2017)

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

Por Rothwell, Simon, Chinoy, Hector, Lamb, Janine A, Miller, Frederick W, Rider, Lisa G, Wedderburn, Lucy R, McHugh, Neil J, Mammen, Andrew L, Betteridge, Zoe E, Tansley, Sarah L, Bowes, John, Vencovský, Jiří, Deakin, Claire T, Dankó, Katalin, Vidya, Limaye, Selva-O'Callaghan, Albert, Pachman, Lauren M, Reed, Ann M, Molberg, Øyvind, Benveniste, Olivier, Mathiesen, Pernille R, Radstake, Timothy R D J, Doria, Andrea, de Bleecker, Jan, Lee, Annette T, Hanna, Michael G, Machado, Pedro M, Ollier, William E, Gregersen, Peter K, Padyukov, Leonid, O'Hanlon, Terrance P, Cooper, Robert G, Lundberg, Ingrid E
Publicado no Ann Rheum Dis (2019)