Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment

Por Petrukhin, Konstantin
Publicado em 2013

DPOFA, a Cl(-)/HCO(3)(- )exchanger antagonist, stimulates fluid absorption across basolateral surface of the retinal pigment epithelium

Por Iserovich, Pavel, Qin, Qiong, Petrukhin, Konstantin
Publicado em 2011

In Pursuit of Synthetic Modulators for the Orphan Retina-Specific Nuclear Receptor NR2E3

Por Qin, Qiong, Knapinska, Anna, Dobri, Nicoleta, Madoux, Franck, Chase, Peter, Hodder, Peter, Petrukhin, Konstantin
Publicado em 2013

Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium

Por Marmorstein, Alan D., Marmorstein, Lihua Y., Rayborn, Mary, Wang, Xinxing, Hollyfield, Joe G., Petrukhin, Konstantin
Publicado em 2000

Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells

Por Chen, Fang, Figueroa, David J., Marmorstein, Alan D., Zhang, Qing, Petrukhin, Konstantin, Caskey, C. Thomas, Austin, Christopher P.
Publicado em 1999

A1120, a Nonretinoid RBP4 Antagonist, Inhibits Formation of Cytotoxic Bisretinoids in the Animal Model of Enhanced Retinal Lipofuscinogenesis

Por Dobri, Nicoleta, Qin, Qiong, Kong, Jian, Yamamoto, Kazunori, Liu, Zhao, Moiseyev, Gennadiy, Ma, Jian-xing, Allikmets, Rando, Sparrow, Janet R., Petrukhin, Konstantin
Publicado em 2013

Haploinsufficiency Is Not the Key Mechanism of Pathogenesis in a Heterozygous Elovl4 Knockout Mouse Model of STGD3 Disease

Por Raz-Prag, Dorit, Ayyagari, Radha, Fariss, Robert N., Mandal, Md Nawajes A., Vasireddy, Vidyullatha, Majchrzak, Sharon, Webber, Andrea L., Bush, Ronald A., Salem, Norman, Petrukhin, Konstantin, Sieving, Paul A.
Publicado em 2006

In Vivo Effect of Mutant ELOVL4 on the Expression and Function of Wild-Type ELOVL4

Por Mandal, Nawajes A., Tran, Julie-Thu A., Zheng, Lixin, Wilkerson, Joseph L., Brush, Richard S., McRae, Joel, Agbaga, Martin-Paul, Zhang, Kang, Petrukhin, Konstantin, Ayyagari, Radha, Anderson, Robert E.
Publicado em 2014

Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

Por Cioffi, Christopher L., Racz, Boglarka, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Stafford, Douglas G., Schwarz, Daniel M. C., Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Dobri, Nicoleta, Michelotti, Enrique, Cywin, Charles L., Martin, William H., Pearson, Paul G., Johnson, Graham, Petrukhin, Konstantin
Publicado no J Med Chem (2015)

Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Diseas...

Por Cioffi, Christopher L., Dobri, Nicoleta, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Stafford, Douglas G., Schwarz, Daniel M. C., Golden, Kathy C., Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Racz, Boglarka, Qin, Qiong, Michelotti, Enrique, Cywin, Charles L., Martin, William H., Pearson, Paul G., Johnson, Graham, Petrukhin, Konstantin
Publicado em 2014