Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

[Image: see text] Accumulation of lipofuscin in the retina is associated with pathogenesis of atrophic age-related macular degeneration and Stargardt disease. Lipofuscin bisretinoids (exemplified by N-retinylidene-N-retinylethanolamine) seem to mediate lipofuscin toxicity. Synthesis of lipofuscin bi...

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Main Authors: Cioffi, Christopher L., Dobri, Nicoleta, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Stafford, Douglas G., Schwarz, Daniel M. C., Golden, Kathy C., Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Racz, Boglarka, Qin, Qiong, Michelotti, Enrique, Cywin, Charles L., Martin, William H., Pearson, Paul G., Johnson, Graham, Petrukhin, Konstantin
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174998/
https://ncbi.nlm.nih.gov/pubmed/25210858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5010013
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