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Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

[Image: see text] Accumulation of lipofuscin in the retina is associated with pathogenesis of atrophic age-related macular degeneration and Stargardt disease. Lipofuscin bisretinoids (exemplified by N-retinylidene-N-retinylethanolamine) seem to mediate lipofuscin toxicity. Synthesis of lipofuscin bi...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Cioffi, Christopher L., Dobri, Nicoleta, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Stafford, Douglas G., Schwarz, Daniel M. C., Golden, Kathy C., Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Racz, Boglarka, Qin, Qiong, Michelotti, Enrique, Cywin, Charles L., Martin, William H., Pearson, Paul G., Johnson, Graham, Petrukhin, Konstantin
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: American Chemical Society 2014
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174998/
https://ncbi.nlm.nih.gov/pubmed/25210858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5010013
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