Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis

Retinol-binding protein 4 (RBP4) serves as a transporter for all-trans-retinol (1) in the blood, and it has been proposed to act as an adipokine. Elevated plasma levels of the protein have been linked to diabetes, obesity, cardiovascular diseases, and nonalcoholic fatty liver disease (NAFLD). Recent...

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Publicado en:J Med Chem
Autores principales: Cioffi, Christopher L., Racz, Boglarka, Varadi, Andras, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Martin, William H., Pearson, Paul G., Johnson, Graham, Blaner, William S., Petrukhin, Konstantin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737539/
https://ncbi.nlm.nih.gov/pubmed/31079449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00352
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