Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

Antagonists of retinol-binding protein 4 (RBP4) impede ocular uptake of serum all-trans retinol (1) and have been shown to reduce cytotoxic bisretinoid formation in the retinal pigment epithelium (RPE), which is associated with the pathogenesis of both dry age-related macular degeneration (AMD) and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Med Chem
Hauptverfasser: Cioffi, Christopher L., Racz, Boglarka, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Stafford, Douglas G., Schwarz, Daniel M. C., Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Dobri, Nicoleta, Michelotti, Enrique, Cywin, Charles L., Martin, William H., Pearson, Paul G., Johnson, Graham, Petrukhin, Konstantin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902181/
https://ncbi.nlm.nih.gov/pubmed/26181715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00423
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge