Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

Eitemau Tebyg

• Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease
  gan: Cioffi, Christopher L., et al.
  Cyhoeddwyd: (2014)
• A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle
  gan: Racz, Boglarka, et al.
  Cyhoeddwyd: (2018)
• Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey
  gan: Racz, Boglarka, et al.
  Cyhoeddwyd: (2020)
• Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis
  gan: Cioffi, Christopher L., et al.
  Cyhoeddwyd: (2019)
• Incidence of Atrophic Lesions in Stargardt Disease in the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Study: Report No. 5
  gan: Strauss, Rupert W., et al.
  Cyhoeddwyd: (2017)