Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

Antagonists of retinol-binding protein 4 (RBP4) impede ocular uptake of serum all-trans retinol (1) and have been shown to reduce cytotoxic bisretinoid formation in the retinal pigment epithelium (RPE), which is associated with the pathogenesis of both dry age-related macular degeneration (AMD) and...

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Publicado en:J Med Chem
Autores principales: Cioffi, Christopher L., Racz, Boglarka, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Stafford, Douglas G., Schwarz, Daniel M. C., Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Dobri, Nicoleta, Michelotti, Enrique, Cywin, Charles L., Martin, William H., Pearson, Paul G., Johnson, Graham, Petrukhin, Konstantin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902181/
https://ncbi.nlm.nih.gov/pubmed/26181715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00423
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