Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis

Retinol-binding protein 4 (RBP4) serves as a transporter for all-trans-retinol (1) in the blood, and it has been proposed to act as an adipokine. Elevated plasma levels of the protein have been linked to diabetes, obesity, cardiovascular diseases, and nonalcoholic fatty liver disease (NAFLD). Recent...

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Cioffi, Christopher L., Racz, Boglarka, Varadi, Andras, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Martin, William H., Pearson, Paul G., Johnson, Graham, Blaner, William S., Petrukhin, Konstantin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737539/
https://ncbi.nlm.nih.gov/pubmed/31079449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00352
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