A1120, a Nonretinoid RBP4 Antagonist, Inhibits Formation of Cytotoxic Bisretinoids in the Animal Model of Enhanced Retinal Lipofuscinogenesis

PURPOSE. Excessive accumulation of lipofuscin is associated with pathogenesis of atrophic age-related macular degeneration (AMD) and Stargardt disease. Pharmacologic inhibition of the retinol-induced interaction of retinol-binding protein 4 (RBP4) with transthyretin (TTR) in the serum may decrease t...

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Hoofdauteurs: Dobri, Nicoleta, Qin, Qiong, Kong, Jian, Yamamoto, Kazunori, Liu, Zhao, Moiseyev, Gennadiy, Ma, Jian-xing, Allikmets, Rando, Sparrow, Janet R., Petrukhin, Konstantin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Association for Research in Vision and Ophthalmology 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544424/
https://ncbi.nlm.nih.gov/pubmed/23211825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10050
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