Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era

Por Pérez-Galán, Patricia, Dreyling, Martin, Wiestner, Adrian
Publicado em 2011

Modular chiral gold(i) phosphite complexes

Por Delpont, Nicolas, Escofet, Imma, Pérez-Galán, Patricia, Spiegl, Dirk, Raducan, Mihai, Bour, Christophe, Sinisi, Riccardo, Echavarren, Antonio M.
Publicado no Catal Sci Technol (2013)

ON 01910.Na is selectively cytotoxic for Chronic Lymphocytic Leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress

Por Chapman, Colby M., Sun, Xiameng, Roschewski, Mark, Aue, Georg, Farooqui, Mohamed, Stennett, Lawrence, Gibellini, Federica, Arthur, Diane, Pérez-Galán, Patricia, Wiestner, Adrian
Publicado em 2012

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

Por Wang, Qiuyan, Mora-Jensen, Helena, Weniger, Marc A., Perez-Galan, Patricia, Wolford, Chris, Hai, Tsonwin, Ron, David, Chen, Weiping, Trenkle, William, Wiestner, Adrian, Ye, Yihong
Publicado em 2009

The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leuke...

Por Rosich, Laia, Saborit-Villarroya, Ifigènia, López-Guerra, Mónica, Xargay-Torrent, Sílvia, Montraveta, Arnau, Aymerich, Marta, Villamor, Neus, Campo, Elias, Pérez-Galán, Patricia, Roué, Gaël, Colomer, Dolors
Publicado em 2013

Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma

Por Rosich, Laia, Montraveta, Arnau, Xargay-Torrent, Sílvia, López-Guerra, Mónica, Roldán, Jocabed, Aymerich, Marta, Salaverria, Itziar, Beà, Sílvia, Campo, Elías, Pérez-Galán, Patricia, Roué, Gaël, Colomer, Dolors
Publicado em 2014

The BET bromodomain inhibitor CPI203 improves lenalidomide and dexamethasone activity in in vitro and in vivo models of multiple myeloma by blockade of Ikaros and MYC signaling

Por Díaz, Tania, Rodríguez, Vanina, Lozano, Ester, Mena, Mari-Pau, Calderón, Marcos, Rosiñol, Laura, Martínez, Antonio, Tovar, Natalia, Pérez-Galán, Patricia, Bladé, Joan, Roué, Gaël, de Larrea, Carlos Fernández
Publicado no Haematologica (2017)

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma

Por Montraveta, Arnau, Xargay-Torrent, Sílvia, López-Guerra, Mónica, Rosich, Laia, Pérez-Galán, Patricia, Salaverria, Itziar, Beà, Silvia, Kalko, Susana G., de Frias, Mercè, Campàs, Clara, Roué, Gaël, Colomer, Dolors
Publicado em 2014

Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma

Por Weniger, Marc A., Rizzatti, Edgar G., Perez-Galan, Patricia, Liu, Delong, Wang, Qiuyan, Munson, Peter J., Raghavachari, Nalini, White, Therese, Tweito, Megan M., Dunleavy, Kieron, Ye, Yihong, Wilson, Wyndham H., Wiestner, Adrian
Publicado em 2011

The Bruton tyrosine kinase inhibitor CC-292 shows activity in mantle cell lymphoma and synergizes with lenalidomide and NIK inhibitors depending on nuclear factor-κB mutational sta...

Por Vidal-Crespo, Anna, Rodriguez, Vanina, Matas-Cespedes, Alba, Lee, Eriong, Rivas-Delgado, Alfredo, Giné, Eva, Navarro, Alba, Beà, Sílvia, Campo, Elias, López-Guillermo, Armando, Lopez-Guerra, Monica, Roué, Gaël, Colomer, Dolors, Pérez-Galán, Patricia
Publicado no Haematologica (2017)

Modeling Tumor-Host Interactions of Chronic Lymphocytic Leukemia in Xenografted Mice to Study Tumor Biology and Evaluate Targeted Therapy

Por Herman, Sarah E. M., Sun, Xiameng, McAuley, Erin M., Hsieh, Matthew M., Pittaluga, Stefania, Raffeld, Mark, Liu, Delong, Keyvanfar, Keyvan, Chapman, Colby M., Chen, Jichun, Buggy, Joseph J., Aue, Georg, Tisdale, John F., Pérez-Galán, Patricia, Wiestner, Adrian
Publicado em 2013

CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia

Por Montraveta, Arnau, Lee-Vergés, Eriong, Roldán, Jocabed, Jiménez, Laura, Cabezas, Sandra, Clot, Guillem, Pinyol, Magda, Xargay-Torrent, Sílvia, Rosich, Laia, Arimany-Nardí, Cristina, Aymerich, Marta, Villamor, Neus, López-Guillermo, Armando, Pérez-Galán, Patricia, Roué, Gaël, Pastor-Anglada, Marçal, Campo, Elías, López-Guerra, Mónica, Colomer, Dolors
Publicado no Oncotarget (2015)

The human CD38 monoclonal antibody daratumumab shows anti-tumor activity and hampers leukemia-microenvironment interactions in chronic lymphocytic leukemia

Por Matas-Céspedes, Alba, Vidal-Crespo, Anna, Rodriguez, Vanina, Villamor, Neus, Delgado, Julio, Giné, Eva, Roca-Ho, Heleia, Menéndez, Pablo, Campo, Elías, López-Guillermo, Armando, Colomer, Dolors, Roué, Gaël, Wiestner, Adrian, Parren, Paul W.H.I., Doshi, Parul, van Bueren, Jeroen Lammerts, Pérez-Galán, Patricia
Publicado no Clin Cancer Res (2016)

Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation

Por Pérez-Galán, Patricia, Mora-Jensen, Helena, Weniger, Marc A., Shaffer, Arthur L., Rizzatti, Edgar G., Chapman, Colby M., Mo, Clifton C., Stennett, Lawrence S., Rader, Christoph, Liu, Poching, Raghavachari, Nalini, Stetler-Stevenson, Maryalice, Yuan, Constance, Pittaluga, Stefania, Maric, Irina, Dunleavy, Kieron M., Wilson, Wyndham H., Staudt, Louis M., Wiestner, Adrian
Publicado em 2011

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells

Por Body, Simon, Esteve-Arenys, Anna, Miloudi, Hadjer, Recasens-Zorzo, Clara, Tchakarska, Guergana, Moros, Alexandra, Bustany, Sophie, Vidal-Crespo, Anna, Rodriguez, Vanina, Lavigne, Régis, Com, Emmanuelle, Casanova, Isolda, Mangues, Ramón, Weigert, Oliver, Sanjuan-Pla, Alejandra, Menéndez, Pablo, Marcq, Bénédicte, Picquenot, Jean-Michel, Pérez-Galán, Patricia, Jardin, Fabrice, Roué, Gaël, Sola, Brigitte
Publicado no Sci Rep (2017)

The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia

Por Herishanu, Yair, Pérez-Galán, Patricia, Liu, Delong, Biancotto, Angélique, Pittaluga, Stefania, Vire, Berengere, Gibellini, Federica, Njuguna, Ndegwa, Lee, Elinor, Stennett, Lawrence, Raghavachari, Nalini, Liu, Poching, McCoy, J. Philip, Raffeld, Mark, Stetler-Stevenson, Maryalice, Yuan, Constance, Sherry, Richard, Arthur, Diane C., Maric, Irina, White, Therese, Marti, Gerald E., Munson, Peter, Wilson, Wyndham H., Wiestner, Adrian
Publicado em 2011