The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL), an incurable malignancy of mature B lymphocytes, involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes (LN). A role of the tissue microenvironment in the pathogenesis of CLL is hypothesized based on in vitro observations, but its contr...

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Detalhes bibliográficos
Main Authors: Herishanu, Yair, Pérez-Galán, Patricia, Liu, Delong, Biancotto, Angélique, Pittaluga, Stefania, Vire, Berengere, Gibellini, Federica, Njuguna, Ndegwa, Lee, Elinor, Stennett, Lawrence, Raghavachari, Nalini, Liu, Poching, McCoy, J. Philip, Raffeld, Mark, Stetler-Stevenson, Maryalice, Yuan, Constance, Sherry, Richard, Arthur, Diane C., Maric, Irina, White, Therese, Marti, Gerald E., Munson, Peter, Wilson, Wyndham H., Wiestner, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031480/
https://ncbi.nlm.nih.gov/pubmed/20940416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-284984
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