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TOSO, the FcµR, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation

TOSO/FAIM3 has recently been identified as the long sought after Fc receptor for IgM (FcµR). FcµR is expressed on human CD19(+) B cells, CD4(+)/CD8(+) T cells, and CD56(+)/CD3(−) NK cells, and has been shown to be overexpressed in chronic lymphocytic leukemia (CLL) cells. CLL is a malignancy of matu...

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Hlavní autoři: Vire, Bérengère, David, Alexandre, Wiestner, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186823/
https://ncbi.nlm.nih.gov/pubmed/21908732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100532
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