Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia

BACKGROUND: In chronic lymphocytic leukemia lenalidomide causes striking immune activation, possibly leading to clearance of tumor cells. We conducted this study to investigate the mechanism of action of lenalidomide and the basis for its unique toxicities in chronic lymphocytic leukemia. DESIGN AND...

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Hlavní autoři: Aue, Georg, Njuguna, Ndegwa, Tian, Xin, Soto, Susan, Hughes, Thomas, Vire, Berengere, Keyvanfar, Keyvan, Gibellini, Federica, Valdez, Janet, Boss, Carol, Samsel, Leigh, McCoy, J. Philip, Wilson, Wyndham H., Pittaluga, Stefania, Wiestner, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2009
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738719/
https://ncbi.nlm.nih.gov/pubmed/19734418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.005835
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