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CD44 signaling via PI3K/AKT and MAPK/ERK pathways protects CLL cells from spontaneous and drug induced apoptosis through MCL-1

Survival of chronic lymphocytic leukemia (CLL) cells in vivo is supported by the tissue microenvironment, which includes components of the extracellular matrix. Interactions between tumor cells and the extracellular matrix are in part mediated by CD44, whose principle ligand in this respect is hyalu...

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Bibliografski detalji
Glavni autori: Herishanu, Yair, Gibellini, Federica, Njuguna, Ndegwa, Hazan-Halevy, Inbal, Keyvanfar, Keyvan, Lee, Elinor, Wilson, Wyndham, Wiestner, Adrian
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403533/
https://ncbi.nlm.nih.gov/pubmed/21649540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2011.569962
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