Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma

PURPOSE: Proteasome inhibition disrupts protein homeostasis and induces apoptosis. Up to 50% of patients with relapsed mantle cell lymphoma (MCL) respond to bortezomib. We used gene expression profiling to investigate the connection between proteasome inhibition, cellular response, and clinical effi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Weniger, Marc A., Rizzatti, Edgar G., Perez-Galan, Patricia, Liu, Delong, Wang, Qiuyan, Munson, Peter J., Raghavachari, Nalini, White, Therese, Tweito, Megan M., Dunleavy, Kieron, Ye, Yihong, Wilson, Wyndham H., Wiestner, Adrian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149767/
https://ncbi.nlm.nih.gov/pubmed/21712452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3367
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