Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma

PURPOSE: Proteasome inhibition disrupts protein homeostasis and induces apoptosis. Up to 50% of patients with relapsed mantle cell lymphoma (MCL) respond to bortezomib. We used gene expression profiling to investigate the connection between proteasome inhibition, cellular response, and clinical effi...

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Huvudupphovsmän: Weniger, Marc A., Rizzatti, Edgar G., Perez-Galan, Patricia, Liu, Delong, Wang, Qiuyan, Munson, Peter J., Raghavachari, Nalini, White, Therese, Tweito, Megan M., Dunleavy, Kieron, Ye, Yihong, Wilson, Wyndham H., Wiestner, Adrian
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149767/
https://ncbi.nlm.nih.gov/pubmed/21712452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3367
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