The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells

Phosphatidylinositol-3-kinase pathway is constitutively activated in chronic lymphocytic leukemia mainly due to microenvironment signals, including stromal cell interaction and CXCR4 and B-cell receptor activation. Because of the importance of phosphatidylinositol-3-kinase signaling in chronic lymph...

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Auteurs principaux: Rosich, Laia, Saborit-Villarroya, Ifigènia, López-Guerra, Mónica, Xargay-Torrent, Sílvia, Montraveta, Arnau, Aymerich, Marta, Villamor, Neus, Campo, Elias, Pérez-Galán, Patricia, Roué, Gaël, Colomer, Dolors
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815175/
https://ncbi.nlm.nih.gov/pubmed/23850807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.088849
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